Nucleofill® 25 Polynucleotide Gel for Clinics

Nucleofill® 25 is an injectable polynucleotide gel for professional skin biostimulation. Clinics deploy this preparation to hydrate tissue, support dermal remodeling, and enhance skin quality across the face, neck, and chest. Teams value consistent US distribution and dependable quality controls. Med Wholesale Supplies serves licensed clinics and healthcare professionals with authentic, brand-name medical products sourced through vetted distributors.

What Nucleofill Is and How It Works

Nucleofill® 25 is a sodium DNA–based polynucleotide gel designed for intradermal administration by trained professionals. The formulation supplies highly purified polynucleotides that can interact with dermal fibroblasts, supporting extracellular matrix renewal. Its hydrophilic backbone helps maintain isosmotic hydration within the matrix, aiding tissue suppleness and turgor. The class is also valued for scavenging reactive species, which can help limit oxidative stress during routine aesthetic workflows. These combined attributes make it a versatile option for textural improvement protocols in mature skin. Clinicians may document the class as Polynucleotide injectable 25 in treatment planning.

This product integrates readily with established injection techniques. It is suited to multi-area use, including the lower face, neck, and upper chest. In practice, clinicians select layered or microdepot placement patterns to address thin dermis and uneven texture. The material’s smooth gel character supports controlled deposition and predictable spread. Procedural decisions remain at the practitioner’s discretion, based on training and patient selection.

Professional Applications

In aesthetic settings, this preparation is used within biostimulation protocols to support skin quality improvement. Typical applications include texture refinement, hydration support, and dermal conditioning across photoexposed zones. Many teams incorporate it into Mesotherapy and Skin Boosters service lines. Schedules are adapted to clinic workflow, often coordinated with energy-based treatments or peel programmes when appropriate. For further reading on clinical positioning and technique considerations, see Skin Booster Guide and Medium PN Overview.

Key Features

• Polynucleotide platform: supports dermal matrix activity and hydration.
• Sodium DNA base: high-purity PN chains for professional use.
• Sterile gel matrix: non-pyrogenic, clinic-grade preparation.
• Consistent rheology: smooth flow for controlled intradermal placement.
• Multi-area flexibility: suitable for face, neck, and upper chest.
• Protocol-friendly: integrates with needle or cannula techniques.
• Oxidative balance: supports defense against reactive species.
• Quality controls: batch traceability and clear lot/expiry labeling.

Benefits in Practice

The material’s handling supports consistent placement and efficient session timing. Its gel behavior helps reduce pass-to-pass variability, assisting providers when standardizing technique across staff. The preparation fits diverse aesthetic pathways, enabling flexible scheduling around combination therapies. By streamlining inventory to a single, versatile class, clinics can simplify training and reduce SKU complexity. For multi-site organizations, unified protocols help maintain uniform outcomes across locations. When evaluating Nucleofill 25 clinic supply within your formulary, consider standard cannula lengths, needle gauges, and post-care options to keep procedures efficient.

In-service teams often note that a PN-based option complements HA-based boosters and collagen stimulators. Cohesive gel behavior can improve control in delicate areas, while maintaining hydration support profiles. This aids patient segmentation, separating those who benefit from PN-first strategies from those better suited to HA or biostimulatory fillers. The approach fosters clearer consultation frameworks and consistent consent discussions.

Composition & Ingredients

• Active component: purified polynucleotides (sodium DNA).
• Vehicle: sterile, buffered gel carrier suitable for intradermal administration.
• Character: hydrophilic, viscoelastic gel designed for even tissue distribution.

No additional excipients are disclosed beyond a sterile gel vehicle suitable for clinical use. The formulation is intended for professional administration by trained, licensed practitioners under appropriate aseptic technique.

Packaging & Supply

This product is supplied in sterile, tamper-evident packaging appropriate for professional environments. Each unit features clear lot and expiry details for traceability in inventory systems. Store according to the label. Avoid extremes of temperature and direct sunlight. Do not use if the packaging is compromised. Dispose of sharps and any residual materials per local guidelines for regulated medical waste.

Ordering & Logistics

Create or verify your professional account to view availability and request volume or contract pricing. Sign in to place orders, assign shipping addresses for each site, and manage invoices. Your team can select preferred carriers and add delivery notes at checkout. Carrier tracking is provided. For support with ordering workflows or documentation requests, contact our account services team.

Comparable Products

Clinics evaluating PN-based options often assess alternatives by viscosity, handling, and portfolio fit. Consider Nucleofill 20 for a lighter option in the same family. For a non-brand alternative, see Medium Strength PN or a hybrid approach such as HA PN Hybrid. For brand-wide assortment, explore the Nucleofill Collection.

Pricing & Access

Sign in to view clinic pricing. Volume breaks and contract tiers are available for qualified accounts. Multi-site organizations can centralize procurement under a single agreement to streamline replenishment and reporting. Quotes can be prepared for tender processes upon request.

Availability & Substitutions

Supply may vary due to manufacturer production cycles and demand. If the requested item is temporarily unavailable, our team can advise on functionally similar PN-based options that fit your workflow. Confirm suitability and protocol adjustments with your clinical leadership before substitution. We do not guarantee restock dates, but we will notify your buyer when inventory updates occur.

Authoritative Sources

• PubMed: Polynucleotide Injectables
• NIH PMC: Skin Biostimulation Overview
• FDA: Medical Devices Overview

Ready to onboard this class into your protocols? Create your account to order with temperature-controlled handling when required and tracked US delivery.