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MONOVISC® Knee Injection: A Single Shot for Osteoarthritis Relief

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Medically Reviewed

Profile image of Lalaine Cheng

Medically Reviewed By Lalaine ChengA dedicated medical practitioner with a Master’s degree in Public Health, specializing in epidemiology with a profound focus on overall wellness and health, brings a unique blend of clinical expertise and research acumen to the forefront of healthcare. As a researcher deeply involved in clinical trials, I ensure that every new medication or product satisfies the highest safety standards, giving you peace of mind, individuals and healthcare providers alike. Currently pursuing a Ph.D. in Biology, my commitment to advancing medical science and improving patient outcomes is unwavering.

Profile image of Lalaine Cheng

Written by Lalaine ChengA dedicated medical practitioner with a Master’s degree in Public Health, specializing in epidemiology with a profound focus on overall wellness and health, brings a unique blend of clinical expertise and research acumen to the forefront of healthcare. As a researcher deeply involved in clinical trials, I ensure that every new medication or product satisfies the highest safety standards, giving you peace of mind, individuals and healthcare providers alike. Currently pursuing a Ph.D. in Biology, my commitment to advancing medical science and improving patient outcomes is unwavering. on March 14, 2025

Monovisc knee injection

Osteoarthritis is a progressive joint disease that impacts millions, causing ongoing discomfort, joint rigidity, and restricted movement. Patients experiencing knee osteoarthritis often seek non-surgical treatment options to reduce discomfort and delay the need for invasive procedures. Among the most effective and long-lasting treatment solutions is the Monovisc knee injection, a single-dose hyaluronic acid injection designed to lubricate and cushion the knee joint, improving mobility and reducing pain.

Unlike other viscosupplementation therapies that require multiple injections over several weeks, this single-shot treatment delivers sustained relief with just one administration. This makes it a preferred option for patients and healthcare providers seeking minimally invasive pain management solutions.

Medical practitioners must understand this injection’s benefits, efficacy, and safety profile to determine the best candidates for treatment. This article provides an in-depth look at how Monovisc injections for knee osteoarthritis work, their clinical advantages, and considerations for patient selection.

How Monovisc Knee Injection Works

Hyaluronic acid is a naturally occurring synovial fluid substance responsible for lubricating and cushioning the knee joint. As osteoarthritis progresses, the natural production of hyaluronic acid declines, leading to increased friction, inflammation, and joint stiffness. Monovisc injection is designed to restore lost lubrication and enhance shock absorption within the knee joint.

The injection contains high-molecular-weight, cross-linked hyaluronic acid, miming healthy synovial fluid properties. Improving joint function helps reduce pain, enhance mobility, and slow the progression of osteoarthritis.

The effects of this injection can last for up to six months, offering longer-lasting relief compared to corticosteroid injections.

Who Can Benefit from Monovisc Injection?

Monovisc injection for knee is ideal for patients experiencing mild to moderate knee osteoarthritis who have not responded well to oral pain medications, physical therapy, or corticosteroid injections. Candidates for this therapy include:

  • Patients looking for a single-dose viscosupplementation treatment instead of multiple injections
  • Individuals experiencing persistent knee pain that interferes with daily activities
  • Patients who want to delay or avoid knee replacement surgery
  • Individuals who have not achieved sufficient relief with NSAIDs or steroid injections
  • Athletes or active individuals looking to maintain mobility and function

What to Expect During the Injection Procedure

While Monovisc provides significant symptom relief, patients must maintain a healthy weight, follow an exercise regimen, and practice joint-friendly habits to maximize benefits. Here’s what to expect during the injection procedure:

Pre-Treatment Preparation

  • The knee joint is cleansed and sterilized to prevent infection.
  • In some cases, excess fluid may be removed from the knee joint before the injection.

Injection Process

  • The injection is administered directly into the knee joint using a fine-gauge needle.
  • The procedure typically takes 10-15 minutes and is performed in an outpatient setting.

Post-Injection Care

  • Patients should avoid high-impact activities for 24-48 hours.
  • Some individuals may experience temporary knee pain after Monovisc injection, which usually subsides within a few days.
  • The full benefits of the injection may take a few weeks to develop, with symptom relief lasting up to six months.

Repeat injections may be administered as needed to maintain long-term relief.

Clinical Efficacy and Research Findings

Numerous clinical studies support the effectiveness of this viscosupplementation therapy. Research has shown that:

  • Patients experience significant pain reduction and improved joint function within weeks of Monovisc treatment.
  • Compared to corticosteroid injections, this treatment provides longer-lasting symptom relief without the risk of cartilage breakdown.
  • A single-dose administration is as effective as multi-dose viscosupplementation regimens, reducing the need for repeated injections.

These findings confirm the safety and efficacy of this single-shot treatment as a viable option for non-surgical osteoarthritis management.

Potential Side Effects of Monovisc

While this injection is generally well-tolerated, healthcare providers should inform patients about possible Monovisc side effects, including:

  • Mild swelling or discomfort at the injection site
  • Temporary joint stiffness or localized warmth
  • Knee pain after one Monovisc dosage, which typically resolves within a few days
  • Rare allergic reactions, particularly in patients with sensitivity to avian-derived products

Severe reactions are uncommon, but patients should be monitored for persistent swelling, severe pain, or signs of infection after the procedure.

How to Buy Monovisc for Your Practice

Healthcare providers seeking to buy Monovisc for their practice should source from a trusted medical distributor to ensure:

  • Authentic, FDA-approved viscosupplements
  • Competitive pricing for bulk orders
  • Reliable shipping and secure transactions

Purchasing from licensed suppliers guarantees patients receive high-quality treatment for effective osteoarthritis management. Buy Monovisc now from MedWholesaleSupplies for competitive pricing, secure transactions, and trusted medical product distribution.

Conclusion

Monovisc knee injection is a single-dose viscosupplement that relieves knee osteoarthritis. Restoring lost lubrication in the joint helps reduce pain, improve mobility, and delay the need for surgical intervention.

For medical practitioners, understanding this treatment’s mechanism of action, patient selection, and clinical benefits is essential for maximizing patient outcomes. As demand for non-invasive osteoarthritis treatments grows, incorporating hyaluronic acid injections into your practice can offer a practical and research-backed solution for knee pain relief.

Frequently Asked Questions (FAQs)

How long does a Monovisc knee injection last?

The effects of this treatment typically last up to six months, although some patients may experience relief for a more extended period. The duration of effectiveness depends on the severity of osteoarthritis, individual joint health, and lifestyle factors such as weight management and activity level. Patients who experience symptom recurrence may receive repeat injections every six months to a year to maintain mobility and pain relief.

What are the most common side effects?

This injection is generally well-tolerated, but some patients may experience mild and temporary side effects. These can include joint stiffness, localized swelling, and mild discomfort at the injection site. Some individuals report warmth or redness around the knee, which usually resolves within a few days. In rare cases, patients may experience an allergic reaction or inflammatory response, particularly if they have sensitivities to hyaluronic acid. 

Is Monovisc for osteoarthritis safe?

Yes, this injection is FDA-approved and widely used for treating knee osteoarthritis. It has undergone extensive clinical trials and real-world use to demonstrate its safety and effectiveness. However, as with any medical treatment, assessing patient history, pre-existing conditions, and potential allergies is essential before administration.

Can Monovisc be used on both knees?

Yes, the injection can be administered to one or both knees, depending on the patient’s level of osteoarthritis and symptoms. Many individuals with bilateral knee osteoarthritis benefit from injections in both joints to improve overall mobility and reduce pain in daily activities. Healthcare providers may administer injections in separate sessions to monitor patient response and minimize discomfort when treating both knees.

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