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Comparing Synvisc and Synvisc One

Post written by admin on April 2, 2024

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what is synvisc

Managing osteoarthritis knee pain poses significant challenges in clinical practice. However, with the advent of advanced medical treatments like Synvisc and Synvisc One, there’s newfound hope for patients. As healthcare providers, understanding the nuances between these two options is paramount for informed decision-making.  With this, we’re going to compare their compositions, administration methods, efficacy, and more to assist you in determining the optimal choice for your patients.

What is Synvisc?

Synvisc injections are primarily indicated for osteoarthritis knee pain in patients who have not responded adequately to conservative non-pharmacologic therapy and simple analgesics like acetaminophen. 

What is Synvisc Used For?

Osteoarthritis, characterized by cartilage breakdown in the joints, leads to pain, stiffness, and reduced mobility. Synvisc supplements the synovial fluid in the knee joint, mimicking its lubricating and cushioning properties, thereby reducing friction and alleviating pain associated with osteoarthritis.

What is Synvisc One?

Synvisc One is a form of viscosupplement administered through a single injection for alleviating knee pain associated with osteoarthritis. The advantage of Synvisc One lies in its one-time treatment approach, contrasting with the multiple injections required with traditional Synvisc, thereby more appealing to healthcare providers or doctors.

Synvisc vs Synvisc One Composition

Synvisc shots consist of the substance hylan, a compound that replicates the lubricating and shock-absorbing functions of natural joint fluid, providing relief from osteoarthritis symptoms.

Synvisc One also contains hylan as its active ingredient. However, it is formulated as a single injection viscosupplement, offering the convenience of a one-time treatment compared to the multi-injection regimen of Synvisc.

Administration of Synvisc and Synvisc One

Treatment with Synvisc typically involves three injections administered over three weeks. This gradual approach aims to restore joint function and alleviate pain progressively.

In contrast, Synvisc One streamlines the treatment process with a single injection, providing immediate relief without the need for multiple appointments.

Dosage: Synvisc vs Synvisc One

The primary distinction between Synvisc and Synvisc One dose lies in their dosage regimens. Synvisc entails a series of three injections, spaced one week apart, with each injection containing 2 ml of solution, totaling 6 ml delivered over the course of treatment. On the other hand, Synvisc One dosage delivers the entire 6 ml in a single injection, offering enhanced convenience.

Safety Profile Between Synvisc and Synvisc One

Both Synvisc and Synvisc One have demonstrated favorable safety profiles, with minimal adverse reactions typically limited to temporary discomfort at the injection site. Serious adverse events are rare but should be monitored closely.

Cost Considerations Between The Two

Cost considerations are essential in treatment decisions. Synvisc One is particularly advantageous for healthcare providers in terms of cost effectiveness, as it involves a single injection protocol. This contrasts with the multi-injection regimen required for traditional Synvisc treatments. Consequently, some doctors prefer Synvisc One as it minimizes the overall cost burden associated with administering multiple injections, making it a more financially favorable option.


Synvisc and Synvisc One present effective options for managing osteoarthritis knee pain, each with its own set of benefits and considerations. Whether opting for the gradual approach of Synvisc or the simplicity of Synvisc One, healthcare providers play a crucial role in guiding patients towards the most suitable treatment option. By comprehensively understanding the comparison between Synvisc and Synvisc One, you can facilitate informed decisions, ultimately enhancing your patient outcomes.

Frequently Asked Questions (FAQs)

What is the difference between Euflexxa vs Synvisc?

Euflexxa and Synvisc are both viscosupplements used to treat osteoarthritis knee pain, but they differ in their composition and administration. Euflexxa contains sodium hyaluronate derived from bacterial fermentation, while Synvisc contains hylan derived from hyaluronan. Additionally, Euflexxa is typically administered as a series of three injections, whereas Synvisc can be given as either a series of three injections or a single injection, depending on the formulation (Synvisc One).

What is the difference between Monovisc vs Synvisc?

The primary difference between Monovisc and Synvisc lies in their administration and composition. Monovisc is a single-injection viscosupplement containing 4 ml of hyaluronan-derived sodium hyaluronate, while Synvisc typically involves three injections spaced one week apart, with each injection containing 2 ml of hylan, a substance derived from hyaluronan. 

What is the difference between Gel One vs Synvisc?

Gel-One and Synvisc are both viscosupplements for knee osteoarthritis, but differ in composition and administration. Gel-One is a single hyaluronate injection derived from bacterial fermentation, while Synvisc involves three hylan injections derived from hyaluronan over several weeks. Both aim to ease knee pain by restoring joint fluid and function, with the choice depending on patient preferences and treatment goals.

What is the difference between Durolane vs Synvisc One?

Durolane and Synvisc One are both viscosupplements used to treat osteoarthritis knee pain, but they have differences in their composition and administration. Durolane contains non-animal stabilized hyaluronic acid (NASHA), while Synvisc One contains hylan derived from hyaluronan.