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Monovisc Vs. Synvisc: Similarities And Differences Explained

Post written by admin on November 4, 2023

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monovisc knee injection

Millions of individuals worldwide endure the debilitating joint condition known as knee osteoarthritis—a condition that results from the gradual deterioration of cartilage within the knee joint, leading to pain, stiffness, and diminished mobility. As the disease progresses, it significantly impacts a person’s quality of life, imposing discomfort and limitations.

While traditional treatments for knee osteoarthritis, such as physical therapy, pain medications, and lifestyle modifications, exist, some individuals seek more effective and longer-lasting relief. In recent years, viscosupplementation has emerged as a promising therapeutic approach. This technique involves the direct injection of a lubricating substance, often hyaluronic acid, into the knee joint. Acting as a shock absorber and joint lubricant, this viscous fluid provides pain relief and enhances joint mobility.

Among the various viscosupplementation options available, Monovisc and Synvisc have gained recognition for their effectiveness in managing knee osteoarthritis. These two products offer hope to individuals striving to alleviate pain and regain their mobility. In this article, we will delve into the details of Monovisc and Synvisc, exploring their similarities and differences, as well as their impact on the treatment of knee osteoarthritis.

Monovisc and Synvisc Defined

Monovisc, manufactured by Anika Therapeutics, is a viscosupplement specifically designed for the treatment of knee osteoarthritis. It is a sterile, clear, and colorless gel-like substance composed primarily of hyaluronic acid – a natural component found in healthy joint synovial fluid. When injected into the knee joint, Monovisc acts as a lubricant and shock absorber, reducing friction, alleviating pain, and improving joint mobility. Typically, a healthcare professional administers Monovisc as a single injection directly into the affected knee joint within a clinical setting. The effects of this treatment can provide pain relief for several months.

On the other hand, Synvisc, produced by Sanofi, is another viscosupplement used in the management of knee osteoarthritis. Similar to Monovisc, it consists of a sterile gel-like substance predominantly composed of hyaluronic acid. When introduced into the knee joint, Synvisc functions as both a lubricant and a cushion, offering relief from pain and enhancing joint mobility. However, the administration of Synvisc differs from that of Monovisc. Synvisc is administered as a series of injections given over a specific timeframe, with the duration influenced by the specific variant of Synvisc used.

Both Synvisc and Monovisc provide viscosupplementation for knee osteoarthritis, offering patients options for managing their condition. While Monovisc is delivered as a single injection, Synvisc involves multiple injections over a defined period. Patients can work with their healthcare providers to determine the most suitable treatment option based on their individual needs and preferences.

Comparing Monovisc and Synvisc


In a pilot study conducted in the European Union, Monovisc demonstrated both safety and effectiveness. More than 90% of patients reported an improvement in pain, and nearly half experienced a significant clinical improvement of 40% or more in the total WOMAC score after six months.

Expanding on these findings, a pivotal study involving 369 patients from the United States and Canada further showcased the potential of Monovisc. This study, evaluated by the FDA, revealed that Monovisc led to a ≥40% improvement in WOMAC Pain score and a ≥15mm improvement compared to baseline. Follow-up assessments were conducted up to 26 weeks after the injection. With its convenient single-injection approach, favorable safety profile, and significant clinical improvements, Monovisc shows promise as a transformative option in managing knee osteoarthritis pain, offering hope to those in search of accessible and effective treatment alternatives.

On the other hand, numerous studies have compared the efficacy of Synvisc to various treatments, including saline injections, steroids, anti-inflammatory drugs, and standard care. Two randomized, placebo-controlled trials provided robust evidence that Synvisc is particularly effective in reducing pain associated with weight-bearing and activity both at the 12 and 26-week marks following treatment.

Additionally, a multi-center trial, where evaluators were unaware of the treatment patients received, demonstrated that the pain relief offered by Synvisc persists longer compared to steroid injections. By the 26-week mark, those who received Synvisc reported significant overall improvement. Furthermore, two multicenter trials evaluated Synvisc against continuous use of anti-inflammatory drugs. One study found both treatments to be equally effective, while the other suggested that Synvisc may provide superior pain relief.

These studies highlight the efficacy of both Monovisc and Synvisc in alleviating pain and improving the symptoms of knee osteoarthritis. The choice between the two depends on individual patient preferences and the recommendations of healthcare professionals.

Adverse Reactions

Monovisc side effects:

  • Joint pain, stiffness, or swelling
  • Itching, numbness, or tingling
  • Headache, dizziness

Synvisc side effects:

  • Knee pain
  • Pain at the injection site
  • Swelling of the knee

While these side effects are usually mild and short-lived, it’s crucial to have a conversation with your healthcare provider if you encounter them.

Duration of Pain Relief

Monovisc offers a notable advantage in providing a long-lasting solution for knee osteoarthritis. Following a single injection, Monovisc’s pain relief often extends over several months, offering patients an extended period of relief from knee pain, stiffness, and discomfort. This convenience can greatly improve the quality of life for patients, reducing the impact of their symptoms. Additionally, Monovisc’s long-lasting effect may reduce the frequency of medical visits, making it an appealing option for individuals with busy schedules or those who prefer fewer medical interventions.

On the other hand, Synvisc adopts a different approach by utilizing a series of injections administered over a specific timeframe. While these injections can effectively alleviate pain, the duration of their effectiveness may vary depending on the specific variant of Synvisc used. Patients considering Synvisc should actively communicate with their healthcare provider to establish their treatment goals and discuss the preferred intervals between injections. This collaborative approach ensures that the treatment plan aligns with the patient’s individual needs and expectations.

Cost Difference

The cost of Monovisc and Synvisc can play a significant role in a patient’s choice between these two osteoarthritis treatments.

According to a comparison by DoctorMedica, the approximate cost of Monovisc treatment in the USA is $1347.77 while the treatment cost of Synvisc is approximately $1073.90 . However, the prices are less when we get them from other countries.

Monovisc typically falls in the price range of $329 to $349, making it a competitive option for those seeking long-lasting knee pain relief. On the other hand, Synvisc is priced between $309 and $329, offering a slightly more affordable alternative.

It is important to note that the price of each syringe or the specific dosage may vary depending on the healthcare provider or insurance coverage. Moreover, these costs are subject to change over time.

Patients looking to access these medications should note that they are available at Med Wholesale Supplies (MWS), providing a reliable source for obtaining Monovisc and Synvisc. We offer patients and healthcare providers a convenient and accessible means of acquiring the treatments they need to manage their osteoarthritis effectively.

Making Informed Choices Between Monovisc and Synvisc

Choosing between Monovisc and Synvisc for the management of knee osteoarthritis requires careful evaluation and consideration of individual needs and preferences. Several factors can influence the decision-making process.

One important consideration is the approach to treatment. Monovisc offers the convenience of a single injection, providing long-lasting pain relief for several months. This can be beneficial for individuals with busy schedules or those who prefer fewer medical interventions. On the other hand, Synvisc involves a series of injections administered over a specified period. While this approach may require more frequent medical visits, it allows for flexibility in dose adjustments and close monitoring of treatment progression.

The duration of pain relief is another crucial aspect. Monovisc has shown promising results in offering extended pain relief, with a single injection providing several months of comfort. In contrast, the duration of Synvisc’s effectiveness may vary depending on the specific variant used and may require additional injections for sustained relief. Discussing individual treatment goals with a healthcare provider can help determine which duration of pain relief aligns better with the patient’s expectations and lifestyle.

Cost can also play a role in decision-making. While the approximate cost of Monovisc treatment in the USA is higher than that of Synvisc, it is important to consider individual insurance coverage and any potential cost differences in specific regions or healthcare systems. Consulting with healthcare providers, insurance companies, or pharmacists can provide accurate and up-to-date information on the cost of each treatment option, including the price of each syringe or specific types.

Ultimately, the choice between Monovisc and Synvisc should be based on a comprehensive evaluation of individual factors such as treatment approach, duration of pain relief, and cost considerations. Engaging in open and informed discussions with healthcare providers can help ensure that the chosen treatment aligns with the patient’s needs, preferences, and lifestyle, leading to an effective and satisfactory management of knee osteoarthritis.