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Orthovisc vs. Synvisc: A Comparison for Knee Osteoarthritis Treatment

Post written by admin on October 30, 2023

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Orthovisc vs. Synvisc: A Comparison for Knee Osteoarthritis Treatment

Meet Amelia, a 58-year-old hiking enthusiast whose knee osteoarthritis had started to limit her outdoor adventures. Her orthopedic specialist suggested Orthovisc, a viscosupplement known for its effectiveness in alleviating knee osteoarthritis symptoms, and also mentioned an alternative treatment, Synvisc. Intrigued, Amelia decided to explore Orthovisc to regain her active lifestyle.

The Orthovisc injections provided relief. Over a few weeks, her pain and stiffness decreased, and she felt more comfortable on hikes. However, Amelia was curious about how Orthovisc compared to Synvisc, the alternative treatment her doctor had mentioned. Could Synvisc serve her a better purpose?

Eager to find an answer, Amelia started comparing Orthovisc and Synvisc. She sought information, read reviews, and explored the effectiveness, safety, potential side effects, and patient experiences of both. If you resonate with Amelia, then this article providing a detailed comparison of Orthovisc and Synvisc is for you. Learn more about knee osteoarthritis to make an informed decision. Stay tuned for valuable insights to find the right choice for you.

Defining Orthovisc and Synvisc

Orthovisc and Synvisc are two viscosupplements used for knee osteoarthritis. Orthovisc, manufactured by Anika Therapeutics, serves as a lubricant and shock absorber in the knee joint. It contains hyaluronic acid, a naturally occurring component in joint fluid. The purpose of Orthovisc is to alleviate pain, improve joint function, and enhance mobility in individuals with knee osteoarthritis.

Synvisc, manufactured by Genzyme Corporation, is another viscosupplement for knee osteoarthritis. Similar to Orthovisc, Synvisc also contains hyaluronic acid. It acts as a lubricant and cushioning agent in the knee joint. Synvisc is primarily used to reduce symptoms associated with knee osteoarthritis, including pain and limited joint mobility. Both Orthovisc and Synvisc aim to provide relief and improve the quality of life for individuals with knee osteoarthritis.

Comparison of Orthovisc and Synvisc for Knee Osteoarthritis Treatment

The significant difference lies in the source of hyaluronic acid used in each product. We get Orthovisc’s hyaluronic acid from bacterial fermentation, while Synvisc uses hyaluronic acid derived from rooster combs.The composition of Synvisc consists of a complex of reticulated Hylan, with Hylan A and Hylan B.

The second significant difference is in their dosage. Orthovisc contains 30mg/2mL of hyaluronic acid, while Synvisc has 16mg/2mL of hyaluronic acid. The injection regimen for Orthovisc involves one weekly injection for three weeks, while the recommended treatment regimen for Synvisc is three injections of 2 mL into the knee joint with one-week intervals in between. 

In the quest for effective knee osteoarthritis treatments, it is vital to determine the advantages and disadvantages of various options. In this comprehensive comparison, we explore Orthovisc and Synvisc to help you make an informed choice for your knee health.


Clinical trials evaluating Orthovisc have shown significant reductions in pain for patients with knee osteoarthritis. In particular, more patients receiving Orthovisc achieved a 40% and 50% reduction in baseline pain compared to those in the placebo groups. This study highlights the substantial pain relief Orthovisc provides, especially when administered in a four-weekly injection regimen.

The clinical studies also showed that Orthovisc’s positive effects persisted over time. Patients experienced significant improvements from Week 7 through 22, indicating that Orthovisc can offer lasting relief for individuals with knee osteoarthritis, enhancing their overall quality of life.

Comparative studies have also evaluated the effectiveness of Synvisc against different control groups. Two randomized, placebo-controlled trials presented compelling evidence that Synvisc is effective in mitigating weight-bearing and activity-related pain at 12 and 26-week milestones. In addition, a multicenter trial conducted in a blinded evaluator’s fashion revealed Synvisc’s enduring efficacy. Compared to intra-articular steroid treatment, Synvisc provided prolonged relief from pain and substantial overall improvement by the 26-week mark.

Two multicenter trials have compared Synvisc to non-steroidal anti-inflammatory drugs (NSAIDs). While one study indicated comparable efficacy between the two treatments, the other suggested that Synvisc may offer superior pain relief.

Overall, both Orthovisc and Synvisc can be effective options for patients with knee osteoarthritis, leading to significant pain reduction and improved joint function. It’s essential to consult with a healthcare provider to determine which treatment option is most suitable for a patient’s specific needs.

Safety and Side Effects

Possible adverse effects of Orthovisc and Synvisc are generally mild and similar. Both products may cause short-term joint pain, joint swelling, and joint effusion. Patients may also experience localized inflammatory reactions such as discomfort, warmth, erythema, itching, and stiffness after intra-articular injection of either Orthovisc or Synvisc. Although rare, a physician should promptly manage adverse severe events, such as allergic reactions, if they occur.

While there are some differences in formulation and viscoelastic properties between Orthovisc and Synvisc, there is no apparent significant variation in their safety profiles. Doctors should carefully review patients’ medical history and current medications before recommending either Orthovisc or Synvisc, as some patients may be at higher risk of complications or interactions.

Overall, both Orthovisc and Synvisc appear to be safe and well-tolerated treatments for knee osteoarthritis, with similar short-term and long-term safety profiles.

Orthovisc vs. Synvisc – Which is Right for You?

When deciding between Orthovisc and Synvisc for knee osteoarthritis treatment, it is essential to consider the options in consultation with a healthcare provider carefully. Both viscosupplements have shown effectiveness in relieving knee pain and improving joint function. However, it would help if you considered several factors when determining which option is best for you:

Individual Response: Each person may respond differently to Orthovisc and Synvisc. Your unique response to treatment can influence which one works better for you.

Medical History: Your medical history and any underlying conditions can impact the decision. It is essential to discuss any allergies, prior treatments, or health conditions with your healthcare provider to ensure the chosen treatment aligns with your medical background.

Treatment Plan: The recommended treatment plan may also influence your choice. Some patients may prefer the convenience of a four-weekly injection regimen offered by Orthovisc, while others may find the schedule of Synvisc more suitable.

Adverse Effects: The likelihood and severity of side effects can vary between the two products. It is essential to discuss any potential side effects and their impact on your daily life with your healthcare provider.

Long-Term Goals: Consider your long-term treatment goals. Do you seek short-term relief or a more sustained effect? Your desired outcome can guide your choice between Orthovisc and Synvisc.

Cost and Insurance: Insurance coverage and cost considerations can also influence your decision. It is advisable to check with your healthcare provider and insurance provider to understand the financial aspect of the treatment.

It is crucial to work closely with a healthcare provider to determine the best course of treatment based on individual factors and medical history. They can provide personalized guidance and make recommendations specific to an individual’s needs and goals.

Please note that this information is for informational purposes only and should not replace professional medical advice.