Nucleofill® 20 Polynucleotide Gel for Clinics

Nucleofill® 20 injection is a sterile polynucleotide gel for professional intradermal use. Clinics deploy this preparation in aesthetic protocols to support skin quality, elasticity, and hydration. Many facilities stock it due to dependable composition and straightforward integration across facial rejuvenation pathways, supported by US distribution.

What Nucleofill Is and How It Works

Nucleofill® 20 is a sodium DNA-based, polynucleotide biostimulator presented as a sterile gel for injection by trained clinicians. This class of products is designed to support dermal structure through three coordinated actions: cellular stimulation, oxidative balance, and iso-osmotic hydration. In practice, the system engages fibroblasts, helps counter oxidative stressors, and retains water within the extracellular matrix. That combination can aid skin quality programs focused on texture and firmness.

This platform is often positioned within Mesotherapy and Skin Boosters categories because of its compatibility with microinjection workflows. As a formulation, the Nucleofill 20 polynucleotide gel maintains a physiologic environment that supports comfort and predictable tissue handling during treatment sessions. Med Wholesale Supplies serves licensed clinics and healthcare professionals with authentic, brand-name medical products sourced through vetted distributors.

Mechanistically, its polynucleotides provide a hydrated scaffold, encourage fibroblast activity linked to collagen-elastin synthesis, and offer antioxidant capacity that helps mitigate free radical burden in stressed skin. The result is a versatile option for clinics building non-volumizing biostimulation plans.

Professional Applications

Clinicians incorporate this polynucleotide gel in comprehensive aesthetic workflows that target dermal quality. It fits well alongside topical care, energy-based device programs, and selected hyaluronic acid products, sequenced at the provider’s discretion. Teams use it to support textural refinement, tone uniformity, and surface hydration in adults seeking skin quality optimization.

Some catalogs categorize these systems as a polynucleotide filler; functionally, this class acts primarily as a biostimulator gel rather than a volumizing implant. To review a protocol overview, see our in-depth article Treatment Overview.

Key Features

• Sterile composition: injectable polynucleotide gel manufactured for clinical use.
• Dermal biostimulation: supports fibroblast engagement for structural maintenance.
• Antioxidant support: helps buffer free radicals in stressed tissue.
• Iso-osmotic hydration: retains water within the extracellular matrix.
• Workflow ready: consistent rheology for microinjection techniques.
• Traceability: lot and expiry details designed for inventory tracking.
• Versatile pairing: complements device-based and topical regimens.

Benefits in Practice

With Nucleofill 20, providers can standardize training around a single biostimulatory platform. Its handling characteristics suit common facial zones and allow predictable placement using standard injection techniques. Practices appreciate its compatibility with staged plans, where biostimulation is combined with other modalities under clinical judgment.

This product also supports efficient inventory management. Clear labeling aids intake and reconciliation. Consistent gel behavior contributes to reproducible sessions across injectors, helping maintain schedule rhythm and patient flow. The class is suitable for diverse phototypes when applied according to professional assessment.

Composition & Ingredients

• Active: highly purified polynucleotides (sodium DNA).
• Vehicle: sterile, iso-osmotic gel matrix appropriate for intradermal use.
• Excipients: buffering components to support physiologic pH.

Formulation details are designed to promote tissue compatibility and maintain hydration within the treated dermal layers. Always consult the current instructions for use included with the product for complete composition information.

Packaging & Supply

This preparation is supplied in sterile, single-use units intended for professional injection. Each unit includes lot number and expiration date for traceability. Labels are clear and scannable, supporting digital stock controls and clinical recordkeeping. Storage and handling should follow the manufacturer’s guidance on the packaging.

For facilities consolidating orders, Nucleofill 20 wholesale access streamlines procurement across multiple sites. Your team can align replenishment cycles with other skin-quality injectables to reduce partial shipments and simplify receiving.

Ordering & Logistics

Account verification is required. Sign in to view availability and request quotes. Contract and volume arrangements are available to eligible practices. If you centralize purchasing, our team can coordinate multi-clinic deliveries and staged releases to match training calendars.

We support Nucleofill 20 US shipping with efficient processing on in-stock items. Packaging focuses on product integrity with protective materials suited to professional injectables. Please follow the included IFU and your facility protocols for storage on arrival.

Comparable Products

Clinics considering polynucleotide systems often evaluate alternatives within the same category. Explore HB Skin Booster for a hyaluronic acid–enhanced option. For another polynucleotide line, review Polynucleotide Repair. Within the brand family, you may also examine Nucleofill Eyes for periocular protocols and 25 Polynucleotides for higher-intensity programs under practitioner judgment.

To browse the broader collection, visit the Nucleofill Line and related categories such as Skin Boosters.

Pricing & Access

Sign in to access current pricing, view available configurations, and request documentation. Volume and contract tiers can be set up for multi-site or high-frequency use. If your formulary requires cross-reference or substitution approval, our support team can prepare formal quotes and product comparison details on request.

While availability fluctuates with manufacturer releases, this product is generally maintained for professional channels. If your facility requires an alternative classification in purchasing systems, list it under polynucleotide biostimulator or polynucleotide gel rather than dermal filler systems.

Availability & Substitutions

Inventory may vary by lot and release timing. If a specific lot is not available, we can suggest compatible substitutes from the same class based on your stated requirements. Substitutions should be vetted by the responsible clinician or medical director before use. We do not make restock guarantees; please contact us for the most current status and lead times.

Authoritative Sources

• NIH/PMC: Polydeoxyribonucleotide in Tissue Repair
• FDA: Biocompatibility Considerations for Medical Devices
• CDC: Injection Safety

Ready to add this biostimulator gel to your formulary? Sign in to order with temperature-controlled handling when required and tracked US delivery.