What It Is
This page provides a clinic-focused comparison of two injectable biologics used in osteoporosis care: Evenity (romosozumab) and Prolia (denosumab). Both are sterile, subcutaneous monoclonal antibody therapies supplied in single-use, prefilled syringes for professional administration. Evenity offers a dual approach that builds and preserves bone mass during a defined 12‑month course, while Prolia is an antiresorptive option designed for ongoing, twice‑yearly maintenance.
For procurement planning, the most common clinic presentations are Evenity romosozumab 210 mg delivered monthly as two 105 mg/1.17 mL prefilled syringes, and Prolia denosumab 60 mg/mL supplied as a single 1 mL prefilled syringe administered every six months.
Professional Applications
These products are incorporated by licensed providers into osteoporosis management pathways for postmenopausal patients at elevated fracture risk. Typical clinical uses include:
- Initiation of an anabolic-first protocol (Evenity 210 mg monthly for 12 months) followed by antiresorptive maintenance (e.g., Prolia 60 mg every six months) to preserve gains.
- Antiresorptive maintenance with Prolia when long-term, twice-yearly dosing aligns with patient adherence and clinic scheduling.
- Protocol design and transitions, including switching from Prolia to Evenity or sequencing Evenity → Prolia, based on the patient’s risk profile, monitoring, and practice standards.
Providers typically support these regimens with DEXA assessments, serum calcium and vitamin D checks, and scheduled follow-ups for adherence and inventory planning.
Key Features
- Form/route: Sterile, preservative-free, single-use prefilled syringes for subcutaneous injection.
- Mechanism: Evenity is bone-forming with antiresorptive activity; Prolia is antiresorptive.
- Dosing cadence: Evenity monthly (two injections per visit); Prolia every six months (single injection).
- Clinic supply formats: Professional-use packs suitable for in-office administration and inventory rotation.
- Wholesale access: Volume tiers and distributor pricing available for licensed facilities.
- Traceability: Lot-controlled, single-patient syringes to support clinic documentation and safety workflows.
Benefits in Practice
- Workflow alignment: Choose a monthly (Evenity) or twice-yearly (Prolia) schedule to fit patient volumes, chair time, and recall systems.
- Inventory efficiency: Predictable cadence simplifies par levels and replenishment for osteoporosis injection clinic supply.
- Ease of administration: Ready-to-use prefilled syringes support consistent dosing and team training.
- Continuity of care: Clear sequencing options help practices standardize protocols from initiation through long-term maintenance.
- Scalable purchasing: Bulk order for clinics with volume pricing helps manage cost per dose across growing patient panels.
Composition
- Evenity (romosozumab): 105 mg/1.17 mL per prefilled syringe; monthly dose supplied as two syringes (total 210 mg). Sterile solution for subcutaneous use.
- Prolia (denosumab): 60 mg/mL in a 1 mL prefilled syringe (single use). Sterile solution for subcutaneous use.
Excipients vary by product and lot; refer to the current prescribing information included with each pack for full composition.
Packaging & Supply
- Evenity professional use pack: Two single-use, prefilled syringes per monthly dose (210 mg total). Clinic supply options support monthly scheduling for 12 months.
- Prolia professional use pack: One single-use, prefilled syringe (60 mg/1 mL) per six-month administration.
- Labeling and SKUs may vary by distributor lot. Shelf-life, storage, and handling instructions are provided in-pack; follow current product labeling.
Ordering & Supply
Licensed clinics, med spas, and healthcare facilities can order after account verification. Volume tiers are available for qualified orders, including Evenity romosozumab injection wholesale and Prolia denosumab prefilled syringe wholesale. Orders ship via tracked US distribution; temperature-controlled handling is provided when required. For ongoing use, many providers set up recurring replenishment aligned to monthly Evenity cycles or twice‑yearly Prolia calendars.
Comparable Products
Authoritative Sources
- FDA Prescribing Information: Evenity (romosozumab)
- FDA Prescribing Information: Prolia (denosumab)
- NIH MedlinePlus: Osteoporosis Overview
Set up your professional account to view distributor pricing, place bulk orders, and schedule clinic delivery for Evenity and Prolia.
