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Exploring the Safety and Efficacy of Orthovisc Injections

Post written by admin on July 3, 2024

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Orthovisc injections, a form of viscosupplementation therapy, have gained considerable acclaim in the medical community for their capacity to alleviate joint pain and improve mobility in patients with osteoarthritis. This article delves into the safety profile, efficacy, and clinical implications of Orthovisc injections.

Orthovisc Injection Uses 

Orthovisc is a sterile, non-pyrogenic solution of highly purified, high molecular weight hyaluronan (hyaluronic acid). Hyaluronic acid naturally resides in the synovial fluid of joints, functioning as both a lubricant and a shock absorber. In osteoarthritis, the synovial fluid becomes thinner and less effective at lubricating the joint, contributing to pain and stiffness.

Orthovisc injections are designed to supplement the natural hyaluronic acid in the joint, providing additional cushioning and lubrication. This treatment aims to minimize pain, enhance joint function, and potentially slow down the advancement of osteoarthritis.

Safety of Orthovisc Injections

The safety profile of Orthovisc injections is generally favorable. Since Orthovisc is derived from purified hyaluronan, a substance naturally present in the body, it is well-tolerated by most patients. Adverse reactions are typically mild and transient, including temporary discomfort or swelling in the injection area.

Serious Orthovisc side effects are rare but can include allergic reactions. Patients with a known allergy to avian proteins or feathers should avoid Orthovisc, as it is derived from chicken combs. As with any medical procedure, healthcare providers must screen patients thoroughly for allergies and medical history before administering Orthovisc injections.

Efficacy of Orthovisc Injections

Orthovisc injections are typically administered in a series, with the exact protocol varying based on the severity of osteoarthritis and the patient’s response to treatment. Many patients experience significant pain reduction and improvement in joint function following the completion of their injection series. The duration of symptom relief can vary among individuals, with some patients experiencing benefits for several months.

According to a study, the effectiveness of Orthovisc for treating knee osteoarthritis (OA) was evaluated in three clinical trials, focusing on two key randomized, controlled, double-masked studies. These studies involved patients receiving either Orthovisc knee injections or arthrocentesis as a control. While the individual analyses of each study did not show statistically significant pain reduction, a combined analysis was performed to gain further insights.

The combined analysis targeted a subgroup of patients with moderate to severe osteoarthritis at baseline. It measured the proportion of patients achieving a 20% improvement and a minimum absolute improvement of 50 mm in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain Score, as well as 40% and 50% improvements at various follow-up points. For this subgroup, the combined data revealed that the primary effectiveness analysis showed trends toward improvement. However, the individual studies alone did not achieve statistical significance, highlighting the complexity of evaluating treatment efficacy for knee osteoarthritis.

Clinical Considerations and Recommendations

Before recommending Orthovisc injections, healthcare providers should conduct a thorough evaluation of the patient’s medical background, current symptoms, and radiographic findings. Patient education is also crucial, ensuring that individuals understand the potential benefits and limitations of Orthovisc therapy.

Orthovisc injections are generally indicated for patients who have not shown sufficient improvement with conservative treatments such as physical therapy, nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroid injections.


Orthovisc injections represent a valuable treatment option for patients suffering from osteoarthritis, particularly in the knee joint. With a commendable safety profile and demonstrated efficacy in pain relief and joint function enhancement, Orthovisc injections can entirely improve the quality of life for many individuals. 

In conclusion, Orthovisc knee injections offer a promising therapeutic approach that aligns with the goal of providing effective symptom relief and improving functional outcomes for patients with osteoarthritis. 

Frequently Asked Questions (FAQs)

How long does it take Orthovisc to work?

Orthovisc typically begins to provide relief from osteoarthritis pain within a few weeks after the initial injection. The full therapeutic effect is often achieved after the completion of the injection series, which may take several weeks.

Where to buy Orthovisc

Orthovisc can be purchased through online pharmaceuticals like Medical Wholesale Supplies (MWS). The website offers convenient access to Orthovisc injections, ensuring patients can obtain the treatment through authorized channels. 

What are the common problems associated with Orthovisc injections?

Common Orthovisc injection problems are generally mild and include temporary pain, swelling, inflammation, and redness at the injection site. Some patients may also experience mild discomfort or stiffness in the treated joint shortly after the injection.  

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